Ah @gregburd it sounds like you are talking about distributed queries. osquery does have facilities for that, but you need to implement a server with the proper APIs (docs: https://osquery.readthedocs.io/en/stable/deployment/remote/). I don't know of any implementation that would be compatible with Presto.
I'm a founder of Kolide and this is a primary feature we support (https://kolide.co). There are also open-source options for distributed queries such as Doorman (https://github.com/mwielgoszewski/doorman)